Abstract
The first asymmetric Michael/cyclization tandem reaction of 4-hydroxycoumarin with nitroolefins catalyzed by chiral bifunctional thioureas was reported and 2,3-dihydrofuro[3,2-c]-coumarin adducts have been obtained in moderate yields (53-75%) and good enantioselectivities (64-90% ee).
Publication types
-
Research Support, Non-U.S. Gov't
MeSH terms
-
4-Hydroxycoumarins / chemistry*
-
Alkenes / chemistry*
-
Catalysis
-
Coumarins / chemical synthesis*
-
Coumarins / chemistry
-
Cyclization
-
Molecular Structure
-
Nitro Compounds / chemistry*
-
Thiourea / chemistry*
Substances
-
2,3-dihydrofuro(3,2-c)-coumarin
-
4-Hydroxycoumarins
-
Alkenes
-
Coumarins
-
Nitro Compounds
-
Thiourea
-
4-hydroxycoumarin