Abstract
TAF7, a component of the TFIID complex, controls the first steps of transcription. It interacts with and regulates the enzymatic activities of transcription factors that regulate RNA polymerase II progression. Its diverse functions in transcription initiation are consistent with its essential role in cell proliferation.
Keywords:
T cells; TAF7; differentiation; proliferation; transcriptional regulation.
Publication types
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Research Support, N.I.H., Intramural
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Review
MeSH terms
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Animals
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Cell Proliferation
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Cyclin-Dependent Kinases / metabolism
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Gene Expression Regulation*
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Humans
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RNA Polymerase II / metabolism
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TATA-Binding Protein Associated Factors
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Transcription Factor TFIID / metabolism*
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Transcription Initiation, Genetic*
Substances
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TAF7 protein, human
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TATA-Binding Protein Associated Factors
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Transcription Factor TFIID
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Cyclin-Dependent Kinases
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RNA Polymerase II