Abstract
A manzamine related alkaloid, zamamiphidin A (1), consisting of a new heptacyclic ring system has been isolated from an Okinawan marine sponge Amphimedon sp. The structure of 1 including the relative stereochemistry was elucidated on the basis of the spectroscopic data. Compound 1 showed antibacterial activity against Staphylococcus aureus (MIC, 32 μg/mL).
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Alkaloids / chemistry
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Alkaloids / isolation & purification*
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Alkaloids / pharmacology
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Animals
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Anti-Bacterial Agents / chemistry
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Anti-Bacterial Agents / isolation & purification*
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Anti-Bacterial Agents / pharmacology
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Carbazoles
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Drug Screening Assays, Antitumor
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Humans
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Japan
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Microbial Sensitivity Tests
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Porifera / chemistry*
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Staphylococcus aureus / drug effects
Substances
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Alkaloids
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Anti-Bacterial Agents
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Carbazoles
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zamamiphidin A
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manzamine A