Abstract
A series of xanthone 1,4-dihydropyridine derivatives were prepared. The compounds were evaluated for inotropic, chronotropic and calcium antagonistic properties. The tested compounds are weak calcium antagonists but exert potent selective bradycardic effects.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Aorta, Thoracic / drug effects
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Chemical Phenomena
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Chemistry, Physical
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Dihydropyridines / pharmacology*
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Female
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Guinea Pigs
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Heart Rate / drug effects*
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In Vitro Techniques
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Male
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Myocardial Contraction / drug effects
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Structure-Activity Relationship
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Xanthenes / pharmacology*
Substances
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Dihydropyridines
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Xanthenes