Hypothermic circulatory arrest using antegrade cerebral perfusion is safe for elective aortic arch surgery

Thorac Cardiovasc Surg. 2013 Oct;61(7):553-8; discussion 558. doi: 10.1055/s-0032-1331466. Epub 2013 Jan 23.

Abstract

Background: We hypothesized that hypothermic circulatory arrest (HCA) can be performed with a low operative risk and does not add to the morbidity in elective procedures.

Methods: A total of 178 patients with a mean (± SD) age of 62 (± 10) years underwent HCA for elective aortic surgery from April 2008 to September 2011. Pre- and postoperative clinical data were collected prospectively.

Results: Hemiarch replacement was performed in 97% patients. Mean logistic Euroscore I was 17% (± 15). HCA was performed at 26°C bilateral tympanic temperature. Mean HCA duration was 17 (±) min. Mean cross-clamp time was 106 (± 39) min. Overall 30-day mortality was 2% and stroke occurred in 4% of patients. Overall 6-month survival was 96%. Cox regression analysis for 6-month survival revealed four variables with significant influence: the logistic Euroscore I (p = 0.008), age (p = 0.04), cross-clamp time (p = 0.008), and reoperation for bleeding complications (p = 0.04).

Conclusions: HCA with open distal anastomosis for elective aortic repair can be performed with low operative mortality, even in the elderly, and seems not to add to the morbidity of the procedure.

MeSH terms

  • Aged
  • Aorta, Thoracic / surgery*
  • Blood Vessel Prosthesis Implantation* / adverse effects
  • Blood Vessel Prosthesis Implantation* / mortality
  • Cerebrovascular Circulation*
  • Chi-Square Distribution
  • Elective Surgical Procedures
  • Female
  • Heart Arrest, Induced* / adverse effects
  • Heart Arrest, Induced* / mortality
  • Humans
  • Hypothermia, Induced* / adverse effects
  • Hypothermia, Induced* / mortality
  • Kaplan-Meier Estimate
  • Logistic Models
  • Male
  • Middle Aged
  • Odds Ratio
  • Operative Time
  • Perfusion / adverse effects
  • Perfusion / methods*
  • Perfusion / mortality
  • Proportional Hazards Models
  • Retrospective Studies
  • Risk Factors
  • Stroke / etiology
  • Stroke / mortality
  • Stroke / physiopathology
  • Stroke / prevention & control*
  • Time Factors
  • Treatment Outcome