Abstract
The biocompatibility of polyacrylamide microcapsules was investigated by implanting microcapsules in the peritoneal cavity or the spleen of rats. The capsules were retrieved every four weeks for twenty weeks. They remained isolated and free in the peritoneal cavity, but led to a slight inflammatory reaction in the spleen. These results were confirmed, in vitro, by determinations of chemiluminescence and interleukin I levels, and by evaluation of attachment and growth of human fibroblasts. The microcapsules did not enhance these inflammatory reactions, and they were a poor support for cellular proliferation.
MeSH terms
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Acrylic Resins*
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Animals
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Biocompatible Materials / adverse effects*
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Capsules / adverse effects
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Cell Adhesion / physiology
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Cell Division
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Fibroblasts / cytology
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Humans
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Inflammation / chemically induced
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Inflammation / pathology
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Interleukin-1 / metabolism
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Luminescent Measurements
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Macrophages / metabolism
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Mice
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Peritoneal Cavity / pathology*
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Peritonitis / chemically induced
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Peritonitis / pathology
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Prostheses and Implants*
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Rats
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Spleen / pathology*
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Splenic Diseases / chemically induced
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Splenic Diseases / pathology
Substances
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Acrylic Resins
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Biocompatible Materials
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Capsules
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Interleukin-1
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polyacrylamide