Abstract
Phosphoinositides are the phosphorylated derivatives of phosphatidylinositol, and play a very significant role in a diverse range of signaling processes in eukaryotic cells. A number of phosphoinositide-metabolizing enzymes, including phosphoinositide-kinases and phosphatases are involved in the synthesis and degradation of these phospholipids. Recently, the function of various phosphatases in the phosphatidylinositol signaling pathway has been of great interest. In the present review we summarize the structural insights and biochemistry of various phosphatases in regulating phosphoinositide metabolism.
Publication types
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Animals
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Dual-Specificity Phosphatases / chemistry
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Dual-Specificity Phosphatases / metabolism
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Humans
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Inositol Polyphosphate 5-Phosphatases
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PTEN Phosphohydrolase / chemistry
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PTEN Phosphohydrolase / metabolism
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Phosphatidylinositol Phosphates / metabolism
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Phosphoric Monoester Hydrolases / chemistry*
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Phosphoric Monoester Hydrolases / genetics
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Phosphoric Monoester Hydrolases / metabolism*
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Protein Structure, Tertiary
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Protein Tyrosine Phosphatases, Non-Receptor / chemistry
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Protein Tyrosine Phosphatases, Non-Receptor / metabolism
Substances
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Phosphatidylinositol Phosphates
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Phosphoric Monoester Hydrolases
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Dual-Specificity Phosphatases
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Protein Tyrosine Phosphatases, Non-Receptor
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myotubularin
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Inositol Polyphosphate 5-Phosphatases
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PTEN Phosphohydrolase
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TPTE2 protein, human