Small molecule disruption of B. subtilis biofilms by targeting the amyloid matrix

Chem Biol. 2013 Jan 24;20(1):5-7. doi: 10.1016/j.chembiol.2013.01.004.

Abstract

Small molecule inhibitors of amyloid aggregation have potential as treatment for a variety of conditions. In this issue of Chemistry & Biology, Romero and colleagues use amyloid-dependent B. subtilis biofilm formation to screen for amyloid inhibitors, identifying compounds that not only inhibit B. subtilis biofilm formation but also ones that disrupt preformed biofilms.

Publication types

  • Comment
  • Research Support, N.I.H., Extramural