A historical perspective on the specific activity of radiopharmaceuticals: what have we learned in the 35years of the ISRC?

Nucl Med Biol. 2013 Apr;40(3):314-20. doi: 10.1016/j.nucmedbio.2012.12.010. Epub 2013 Jan 26.

Abstract

Specific Activity (SA), defined as the amount of radioactivity per unit mass of a compound is arguably one of the most important parameters in radiopharmaceutical development, particularly in quality control of carbon-11 and fluorine-18 labeled compounds. This review article will outline the progression of improvements in SA over the last few decades. The International Symposium of Radiopharmaceutical Chemistry (ISRC/ISRS) abstracts were an excellent source of materials for this review and will be referenced throughout.

Publication types

  • Historical Article

MeSH terms

  • Congresses as Topic / history*
  • Contrast Media / chemistry
  • Contrast Media / metabolism
  • Databases, Pharmaceutical
  • History, 20th Century
  • History, 21st Century
  • Molecular Imaging
  • Radiochemistry*
  • Radiopharmaceuticals / chemistry*
  • Radiopharmaceuticals / metabolism

Substances

  • Contrast Media
  • Radiopharmaceuticals