Abdominal relaxation during emergence from general anesthesia with propofol and remifentanil

J Clin Anesth. 2013 Mar;25(2):106-9. doi: 10.1016/j.jclinane.2012.06.025. Epub 2013 Jan 25.

Abstract

Study objective: To characterize respiratory dynamics during emergence from propofol-remifentanil anesthesia using noninvasive respiratory inductance plethysmography (RIP).

Design: Observational pilot study.

Setting: Operating room in a university-affiliated teaching hospital.

Patients: 50 ASA physical status 1, 2, and 3 patients scheduled for microdirect laryngoscopy or bronchoscopy using total intravenous anesthesia (TIVA) with high-frequency jet ventilation.

Interventions: Patients were fitted with plethysmography bands around the chest and abdomen prior to induction. Following completion of surgery in patients undergoing brief airway procedures using propofol-remifentanil general anesthesia, the anesthetic infusions were stopped and ventilation suspended until resumption of spontaneous ventilation or desaturation below 90%. During this period of apnea, abdominal and thoracic girth was assessed with noninvasive RIP.

Measurements: Cross-sectional area of the thorax and abdomen during emergence were measured.

Main results: Useful data were obtained from 41 patients, with stable apnea lasting 404 ± 193.1 seconds; of these, 34 exhibited a slow and significant decrease in abdominal girth over a period of 267.8 ± 128.5 seconds. Resumption of spontaneous ventilation generally coincided with the end of this abdominal relaxation.

Conclusion: Slow expiration is the initial step in the resumption of spontaneous ventilation during apnea induced with TIVA using propofol-remifentanil.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Abdominal Muscles / drug effects*
  • Abdominal Muscles / physiology
  • Anesthesia Recovery Period
  • Anesthesia, Intravenous / methods
  • Anesthetics, Combined / pharmacology
  • Anesthetics, Intravenous / pharmacology*
  • Apnea / chemically induced
  • Apnea / pathology
  • Apnea / physiopathology
  • Bronchoscopy
  • Exhalation / physiology
  • High-Frequency Jet Ventilation
  • Humans
  • Laryngoscopy
  • Monitoring, Physiologic / methods
  • Muscle Relaxation / drug effects
  • Muscle Relaxation / physiology
  • Pilot Projects
  • Piperidines / pharmacology*
  • Plethysmography / methods
  • Postoperative Care / methods
  • Propofol / pharmacology*
  • Remifentanil
  • Respiratory Mechanics / drug effects*
  • Respiratory Mechanics / physiology

Substances

  • Anesthetics, Combined
  • Anesthetics, Intravenous
  • Piperidines
  • Remifentanil
  • Propofol