Abstract
Phosphocholination of eukaryotic host cell proteins has recently been identified as a novel post-translational modification important for bacterial pathogenesis. Here, we describe the first straightforward synthetic strategy for peptides containing phosphocholinated serine, threonine, or tyrosine residues using preformed functional amino acid building blocks, fully compatible with standard Fmoc solid-phase peptide synthesis.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Amino Acids / chemistry*
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Fluorenes / chemistry*
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Peptides / chemical synthesis*
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Peptides / chemistry*
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Phosphorylcholine / chemical synthesis*
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Phosphorylcholine / chemistry*
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Serine / chemistry*
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Solid-Phase Synthesis Techniques
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Threonine / chemistry*
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Tyrosine / chemistry*
Substances
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9-fluorenylmethoxycarbonyl
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Amino Acids
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Fluorenes
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Peptides
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Phosphorylcholine
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Threonine
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Tyrosine
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Serine