Modeling height for children born small for gestational age treated with growth hormone

Stat Methods Med Res. 2014 Aug;23(4):333-45. doi: 10.1177/0962280212473320. Epub 2013 Feb 1.

Abstract

The analysis of growth curves of children can be done on either the original scale or in standard deviation scores. The first approach is found in many statistical textbooks, while the second approach is common in endocrinology, for instance in the evaluation of the effect of growth hormone in children that are born small for gestational age that remain small later in childhood. We illustrate here that the second approach may involve more complex modeling and hence a worse model fit.

Keywords: Bayesian models; Longitudinal studies; growth hormones; height; human growth; standard deviation scores.

MeSH terms

  • Bayes Theorem
  • Body Height* / drug effects
  • Child
  • Female
  • Gestational Age
  • Growth Hormone / pharmacology
  • Growth Hormone / therapeutic use*
  • Humans
  • Infant, Newborn
  • Infant, Small for Gestational Age / growth & development*
  • Longitudinal Studies
  • Male

Substances

  • Growth Hormone