Osmotic regulation of seamless tube growth

Nat Cell Biol. 2013 Feb;15(2):137-9. doi: 10.1038/ncb2683.

Abstract

Most organs are composed of tubes of differing cellular architectures, including intracellular 'seamless' tubes. Two studies examining the morphogenesis of the seamless tubes formed by the excretory canal cell in Caenorhabditis elegans reveal a previously unappreciated role for osmoregulation of tubulogenesis: hyperosmotic shock recruits canalicular vesicles to the lumenal membrane to promote seamless tube growth.

Publication types

  • Comment

MeSH terms

  • Animals
  • Aquaporins / metabolism*
  • Caenorhabditis elegans / metabolism*
  • Caenorhabditis elegans Proteins / metabolism*
  • Cell Membrane / metabolism*
  • Cytoskeletal Proteins / metabolism*
  • Homeodomain Proteins / metabolism*
  • Humans
  • Lymphangiogenesis*
  • Lymphatic Vessels / metabolism*
  • Prospero-Related Homeobox 1 Protein
  • Tumor Suppressor Proteins / metabolism*
  • Water-Electrolyte Balance*

Substances

  • Aquaporins
  • Caenorhabditis elegans Proteins
  • Cytoskeletal Proteins
  • ERM-1 protein, C elegans
  • Homeodomain Proteins
  • Tumor Suppressor Proteins
  • aquaporin 8
  • Prospero-Related Homeobox 1 Protein