Abstract
A practically simple three-component chiral derivatization protocol for determining the enantiopurity of chiral hydroxylamines by (1)H NMR spectroscopic analysis is described, involving their treatment with 2-formylphenylboronic acid and enantiopure BINOL to afford a mixture of diastereomeric nitrono-boronate esters whose ratio is an accurate reflection of the enantiopurity of the parent hydroxylamine.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Benzaldehydes / chemistry*
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Boronic Acids / chemistry*
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Combinatorial Chemistry Techniques
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Esters
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Hydroxylamines / chemistry*
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Magnetic Resonance Spectroscopy / methods*
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Molecular Structure
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Naphthols / chemistry
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Stereoisomerism
Substances
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2-formylphenylboronic acid
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BINOL, naphthol
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Benzaldehydes
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Boronic Acids
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Esters
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Hydroxylamines
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Naphthols