Abstract
Influenza A viruses are characterized by their ability to evade host immunity, even in vaccinated individuals. To determine how prior immunity shapes viral diversity in vivo, we studied the intra- and interhost evolution of equine influenza virus in vaccinated horses. Although the level and structure of genetic diversity were similar to those in naïve horses, intrahost bottlenecks may be more stringent in vaccinated animals, and mutations shared among horses often fall close to putative antigenic sites.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Evolution, Molecular*
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Genetic Variation
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Horse Diseases / immunology
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Horse Diseases / prevention & control*
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Horse Diseases / virology
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Horses
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Influenza A Virus, H3N8 Subtype / genetics*
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Influenza A Virus, H3N8 Subtype / immunology*
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Influenza A Virus, H3N8 Subtype / isolation & purification
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Molecular Sequence Data
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Orthomyxoviridae Infections / immunology
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Orthomyxoviridae Infections / prevention & control
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Orthomyxoviridae Infections / veterinary*
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Orthomyxoviridae Infections / virology
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RNA, Viral / genetics*
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Selection, Genetic
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Sequence Analysis, DNA