Abstract
We selected 180 clinical isolates of the Mycobacterium tuberculosis complex (MTBC) from patients in China and performed comparative sequence analysis of the mpt64 gene after amplification. From the results, we found that polymorphisms of the mpt64 gene in the MTBC may be the reason for changes in the antigen produced, which may in turn cause alterations of related functions, thereby allowing immune evasion.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Antigens, Bacterial / chemistry
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Antigens, Bacterial / genetics*
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Antigens, Bacterial / immunology*
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Base Sequence
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China
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Humans
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Immune Evasion
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Molecular Sequence Data
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Mycobacterium tuberculosis / genetics*
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Mycobacterium tuberculosis / immunology*
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Mycobacterium tuberculosis / isolation & purification
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Nucleic Acid Amplification Techniques
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Polymorphism, Single Nucleotide
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Protein Structure, Tertiary
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Sequence Analysis, DNA
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Tuberculosis / microbiology
Substances
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Antigens, Bacterial
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MPT64 protein, Mycobacterium tuberculosis