Intestinal regeneration: YAP-tumor suppressor and oncoprotein?

Curr Biol. 2013 Feb 4;23(3):R110-2. doi: 10.1016/j.cub.2012.12.021.

Abstract

The Hippo signaling pathway exerts a growth-suppressive effect by inhibitory phosphorylation of the oncogenic transcription co-activator Yki/YAP. A recent study paradoxically reports that genetic removal of YAP enhances intestinal stem cell expansion and regeneration.

MeSH terms

  • Adaptor Proteins, Signal Transducing / metabolism*
  • Animals
  • Cell Cycle Proteins
  • Drosophila Proteins / metabolism*
  • Hippo Signaling Pathway
  • Humans
  • Intestines / physiology*
  • Intracellular Signaling Peptides and Proteins / metabolism
  • Nuclear Proteins / metabolism*
  • Oncogene Proteins / metabolism
  • Phosphoproteins / metabolism*
  • Protein Serine-Threonine Kinases / metabolism
  • Regeneration*
  • Stem Cells / physiology*
  • Trans-Activators / metabolism*
  • Tumor Suppressor Proteins / metabolism
  • YAP-Signaling Proteins

Substances

  • Adaptor Proteins, Signal Transducing
  • Cell Cycle Proteins
  • Drosophila Proteins
  • Intracellular Signaling Peptides and Proteins
  • Nuclear Proteins
  • Oncogene Proteins
  • Phosphoproteins
  • Trans-Activators
  • Tumor Suppressor Proteins
  • YAP-Signaling Proteins
  • Yap1 protein, mouse
  • Yki protein, Drosophila
  • Protein Serine-Threonine Kinases
  • hpo protein, Drosophila