Activation and degradation of mitofusins: two pathways regulate mitochondrial fusion by reversible ubiquitylation

Nils Wiedemann; Sebastian B Stiller; Nikolaus Pfanner

doi:10.1016/j.molcel.2013.01.027

Activation and degradation of mitofusins: two pathways regulate mitochondrial fusion by reversible ubiquitylation

Mol Cell. 2013 Feb 7;49(3):423-5. doi: 10.1016/j.molcel.2013.01.027.

Authors

Nils Wiedemann¹, Sebastian B Stiller, Nikolaus Pfanner

Affiliation

¹ Institut für Biochemie und Molekularbiologie, ZBMZ, Universität Freiburg, 79104 Freiburg, Germany.

PMID: 23395273
DOI: 10.1016/j.molcel.2013.01.027

Abstract

Mitofusins are large GTPases essential for mitochondrial fusion. In this issue, Anton et al. (2013) report that two independent pathways of ubiquitylation/deubiquitylation control activation and degradation of mitofusins, revealing a sophisticated mechanism of regulating mitochondrial dynamics.

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