Pyrrole and furan oligoglycosides from the starfish Asterina batheri and their inhibitory effect on the production of pro-inflammatory cytokines in lipopolysaccharide-stimulated bone marrow-derived dendritic cells

Bioorg Med Chem Lett. 2013 Mar 15;23(6):1823-7. doi: 10.1016/j.bmcl.2013.01.032. Epub 2013 Jan 23.

Abstract

Three new pyrrole oligoglycosides, astebatheriosides A-C (1-3), and a new furan oligoglycoside, astebatherioside D (4), were isolated from the starfish Asterina batheri by various chromatographic methods. Their structures were elucidated by spectroscopic and chemical methods. Compounds 2, 3, and 4 moderately inhibited IL-12 p40 production in lipopolysaccharide (LPS)-stimulated bone marrow-derived dendritic cells (BMDCs) with IC50 values of 36.4, 31.6, and 22.8μM, respectively.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Asterina / chemistry*
  • Bone Marrow Cells / cytology
  • Cells, Cultured
  • Cytokines / metabolism*
  • Dendritic Cells / cytology
  • Dendritic Cells / drug effects
  • Dendritic Cells / metabolism*
  • Furans / chemistry
  • Glycosides / chemistry*
  • Glycosides / isolation & purification
  • Glycosides / pharmacology
  • Interleukin-12 Subunit p40 / metabolism
  • Interleukin-6 / metabolism
  • Lipopolysaccharides / toxicity
  • Magnetic Resonance Spectroscopy
  • Molecular Conformation
  • Pyrroles / chemistry
  • Tumor Necrosis Factor-alpha / metabolism

Substances

  • Cytokines
  • Furans
  • Glycosides
  • Interleukin-12 Subunit p40
  • Interleukin-6
  • Lipopolysaccharides
  • Pyrroles
  • Tumor Necrosis Factor-alpha
  • furan