Hemifluorinated maltose-neopentyl glycol (HF-MNG) amphiphiles for membrane protein stabilisation

Chembiochem. 2013 Mar 4;14(4):452-5. doi: 10.1002/cbic.201200759. Epub 2013 Feb 10.

Abstract

SOAP OPERA: Fluorinated amphiphile F4-MNG confers greater stability on Rhodobacter capsulatus superassembly relative to conventional detergents and nonfluorinated MNGs. Such amphiphiles are attractive as tools for membrane science because of their ease of preparation and structure variation.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Bacterial Proteins / chemistry*
  • Glycols / chemistry*
  • Halogenation
  • Maltose / analogs & derivatives*
  • Membrane Proteins / chemistry*
  • Protein Stability / drug effects
  • Rhodobacter capsulatus / chemistry*
  • Solubility
  • Surface-Active Agents / chemistry*

Substances

  • Bacterial Proteins
  • Glycols
  • Membrane Proteins
  • Surface-Active Agents
  • Maltose