Abstract
Here, we report the fabrication of a novel ε-caprolactam-silica (ε-SiO2) network and assessed its biocompatibility and ability to improve the antimicrobial activity of kanamycin. The results of the quantitative antimicrobial assay demonstrate that the obtained ε-SiO2 network has efficiently improved the kanamycin activity on Staphylococcus aureus ATCC 25923 and Escherichia coli ATCC 25922 strains, with a significant decrease of the minimum inhibitory concentration. The ε-SiO2 network could be feasibly obtained and represents an alternative for the design of new antibiotic drug carriers or delivery systems to control bacterial infections.
Copyright © 2013 Elsevier B.V. All rights reserved.
Publication types
-
Research Support, Non-U.S. Gov't
MeSH terms
-
Anti-Bacterial Agents / administration & dosage*
-
Anti-Bacterial Agents / chemistry
-
Caprolactam / administration & dosage*
-
Caprolactam / chemistry
-
Drug Carriers / administration & dosage*
-
Drug Carriers / chemistry
-
Drug Synergism
-
Escherichia coli / drug effects
-
Escherichia coli / growth & development
-
Kanamycin / administration & dosage*
-
Kanamycin / chemistry
-
Microbial Sensitivity Tests
-
Microscopy, Electron, Scanning
-
Silicon Dioxide / administration & dosage*
-
Silicon Dioxide / chemistry
-
Spectroscopy, Fourier Transform Infrared
-
Staphylococcus aureus / drug effects
-
Staphylococcus aureus / growth & development
-
X-Ray Diffraction
Substances
-
Anti-Bacterial Agents
-
Drug Carriers
-
Kanamycin
-
Caprolactam
-
Silicon Dioxide