ZDHHC8 gene may play a role in cortical volumes of patients with schizophrenia

Schizophr Res. 2013 Apr;145(1-3):33-5. doi: 10.1016/j.schres.2013.01.011. Epub 2013 Feb 8.

Abstract

ZDHHC8 rs175174 polymorphism is located in 22q11.2 region and its role in brain volume has not been fully addressed. A total of 282 schizophrenia patients and 379 controls were genotyped. A sample of 138 patients underwent brain MRI scan. No association was found between schizophrenia and genotypes. Nevertheless, GG-genotype carriers presented gray matter volume (GMV) reduction in frontal lobe compared to A-allele carriers, and cerebellar hemispheres GMV reductions were found in G-allele carriers compared to AA-genotype. Moreover, A-allele carriers presented posterior brain GMV reductions when compared to GG-genotype. These data suggest that ZDHHC8 may play a role in cortical volumes.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Acyltransferases / genetics*
  • Adult
  • Aged
  • Analysis of Variance
  • Cerebral Cortex / pathology*
  • Female
  • Genetic Predisposition to Disease*
  • Genotype
  • Humans
  • Image Processing, Computer-Assisted
  • Magnetic Resonance Imaging
  • Male
  • Membrane Proteins / genetics*
  • Middle Aged
  • Polymorphism, Single Nucleotide / genetics*
  • Schizophrenia / genetics*
  • Schizophrenia / pathology*

Substances

  • Membrane Proteins
  • Acyltransferases
  • ZDHHC8 protein, human