Abstract
To elucidate the mode of viral persistence in primate lentivirus-infected individuals during combination antiretroviral therapy (cART), four simian immunodeficiency virus 239-infected monkeys were treated with cART for 1 year. The viral env genes prepared from total RNA extracted from the mesenteric lymph nodes collected at the completion of therapy were assessed by single genome amplification. Analyses of nucleotide substitutions and phylogeny revealed no viral evolution during cART.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Anti-Retroviral Agents / administration & dosage*
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Antiretroviral Therapy, Highly Active
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Evolution, Molecular*
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Gene Products, env / genetics
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Lymph Nodes / virology*
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Macaca mulatta
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Phylogeny
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Point Mutation
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Sequence Analysis, DNA
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Simian Acquired Immunodeficiency Syndrome / drug therapy*
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Simian Acquired Immunodeficiency Syndrome / virology*
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Simian Immunodeficiency Virus / classification*
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Simian Immunodeficiency Virus / genetics*
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Simian Immunodeficiency Virus / isolation & purification
Substances
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Anti-Retroviral Agents
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Gene Products, env