Association of the candidate gene SLC1A1 and obsessive-compulsive disorder in Han Chinese population

Haisu Wu; Xuemei Wang; Shunying Yu; Dongxiang Wang; Jianhua Chen; Kaida Jiang; Liping Zhu; Zeping Xiao; Drew Fralick

doi:10.1016/j.psychres.2012.12.016

Association of the candidate gene SLC1A1 and obsessive-compulsive disorder in Han Chinese population

Psychiatry Res. 2013 Oct 30;209(3):737-9. doi: 10.1016/j.psychres.2012.12.016. Epub 2013 Feb 12.

Authors

Haisu Wu¹, Xuemei Wang, Shunying Yu, Dongxiang Wang, Jianhua Chen, Kaida Jiang, Liping Zhu, Zeping Xiao, Drew Fralick

Affiliation

¹ Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, 200030, Shanghai, China.

PMID: 23411042
DOI: 10.1016/j.psychres.2012.12.016

Abstract

This case-control study enrolled 578 obsessive-compulsive disorder (OCD) patients and 649 controls and genotyped rs10491734, rs2228622, rs301430 and rs301443 to replicate association of the SLC1A1 gene with OCD in ethnic Han Chinese. The G-A-C-G and G-G-T-C haplotypes were found to be significantly associated with OCD in overall samples, male samples and female samples.

Keywords: Glutamate transporter gene; Haplotype; Obsessive–compulsive disorder.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Asian People / ethnology
Asian People / genetics
Case-Control Studies
Excitatory Amino Acid Transporter 3 / genetics*
Female
Gene Frequency
Genetic Association Studies
Genetic Predisposition to Disease*
Genotype
Humans
Linkage Disequilibrium
Male
Obsessive-Compulsive Disorder / epidemiology
Obsessive-Compulsive Disorder / ethnology
Obsessive-Compulsive Disorder / genetics*
Polymorphism, Single Nucleotide / genetics*

Substances

Excitatory Amino Acid Transporter 3
SLC1A1 protein, human