Abstract
Recently, we showed that E2F7 and E2F8 (E2F7/8) are critical regulators of angiogenesis through transcriptional control of VEGFA in cooperation with HIF. (1) Here we investigate the existence of other novel putative angiogenic E2F7/8-HIF targets, and discuss the role of the RB-E2F pathway in regulating angiogenesis during embryonic and tumor development.
Keywords:
E2F; HIF; RB; VEGF; angiogenesis; cancer; hypoxia.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Binding Sites
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E2F Transcription Factors / deficiency
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E2F Transcription Factors / genetics
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E2F Transcription Factors / metabolism*
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Humans
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Hypoxia-Inducible Factor 1 / metabolism*
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Neoplasms / metabolism
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Neoplasms / pathology
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Neovascularization, Pathologic
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Receptors, Vascular Endothelial Growth Factor / metabolism
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Repressor Proteins / metabolism*
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Vascular Endothelial Growth Factor A / metabolism
Substances
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E2F Transcription Factors
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Hypoxia-Inducible Factor 1
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Repressor Proteins
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Vascular Endothelial Growth Factor A
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Receptors, Vascular Endothelial Growth Factor