Abstract
The first example of synchrotron X-ray fluorescence imaging of cultured mammalian cells in cyclic peptide research is reported. The study reports the first quantitative analysis of the incorporation of a bromine-labelled cyclic RGD peptide and its effects on the biodistribution of endogenous elements (for example, K and Cl) within individual tumor cells.
Keywords:
RGD peptide; XRF; microprobe; tumor cells.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, Non-P.H.S.
MeSH terms
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Animals
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Bromine
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Humans
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Lung Neoplasms / metabolism*
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Melanoma, Experimental / metabolism*
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Mice
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Neovascularization, Pathologic / prevention & control
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Oligopeptides / chemistry
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Oligopeptides / metabolism
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Peptides, Cyclic / chemistry*
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Peptides, Cyclic / pharmacokinetics*
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Spectrometry, X-Ray Emission / methods
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Tumor Cells, Cultured
Substances
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Oligopeptides
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Peptides, Cyclic
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cyclic arginine-glycine-aspartic acid peptide
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arginyl-glycyl-aspartic acid
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Bromine