Abstract
This chapter summarizes the current knowledge on gene copy number changes found in lung tumors, and their application in the diagnosis, prognostication, and prediction of response to chemotherapy. Examples of the identification of specific "driver" oncogenes within amplified DNA segments are described. A model of how array-CGH could be integrated clinically into the routine workup of lung cancers in clinical laboratory is proposed.
Publication types
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Adenocarcinoma / diagnosis
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Adenocarcinoma / genetics
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Animals
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Carcinoma, Bronchogenic / diagnosis
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Carcinoma, Bronchogenic / genetics
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Carcinoma, Large Cell / diagnosis
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Carcinoma, Large Cell / genetics
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Carcinoma, Squamous Cell / diagnosis
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Carcinoma, Squamous Cell / genetics
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Comparative Genomic Hybridization / methods*
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DNA Copy Number Variations*
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Gene Dosage
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Humans
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Lung / metabolism
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Lung Neoplasms / diagnosis
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Lung Neoplasms / genetics*
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Mesothelioma / diagnosis
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Mesothelioma / genetics
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Pleural Neoplasms / diagnosis
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Pleural Neoplasms / genetics
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Prognosis