Abstract
3-Acetamido-5-iodo-6-aminoacridine (3), a derivative of the known intercalating agent proflavine (3,6-diaminoacridine) (1) was synthesized, and no-carrier-added 123I and 125I labeled compounds prepared. Compound 3 was taken up by live cells and localized in the nucleus. The intracellular concentration of [125I]3 was 7-fold greater in human prostate carcinoma (PC-3) cells than in normal Chinese hamster lung fibroblast (V-79) cells.
Publication types
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Acridines / chemical synthesis*
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DNA / metabolism
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Humans
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In Vitro Techniques
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Intercalating Agents / chemical synthesis*
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Intercalating Agents / metabolism
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Intercalating Agents / pharmacokinetics
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Iodine Radioisotopes / therapeutic use
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Isotope Labeling
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Male
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Proflavine / analogs & derivatives
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Proflavine / chemical synthesis*
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Proflavine / metabolism
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Proflavine / pharmacokinetics
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Prostatic Neoplasms / metabolism
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Prostatic Neoplasms / radiotherapy
Substances
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Acridines
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Intercalating Agents
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Iodine Radioisotopes
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3-acetamido-5-iodoproflavine
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DNA
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Proflavine