Abstract
Hyperbranched polymers conjugated to a peptide-aptamer were prepared using a combination of RAFT polymerisation and click chemistry for targeting tumour cells in vivo. The polymers showed enhanced cell-uptake in vitro (compared to unconjugated polymer) while excellent specificity for solid tumours was observed in vivo using a mouse model of melanoma.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Aptamers, Peptide / chemical synthesis*
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Aptamers, Peptide / pharmacokinetics
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Drug Delivery Systems*
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Fluorescent Dyes
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Injections, Intravenous
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Injections, Subcutaneous
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Melanoma, Experimental / pathology*
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Methacrylates / chemical synthesis*
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Methacrylates / pharmacokinetics
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Mice
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Mice, Inbred C57BL
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Molecular Imaging / methods
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Polyethylene Glycols / chemical synthesis*
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Polyethylene Glycols / pharmacokinetics
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Rhodamines
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Skin Neoplasms / pathology*
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Xenograft Model Antitumor Assays
Substances
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Aptamers, Peptide
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Fluorescent Dyes
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Methacrylates
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Rhodamines
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polyethylene glycol methacrylate
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Polyethylene Glycols
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rhodamine B