Discovery of novel materials with broad resistance to bacterial attachment using combinatorial polymer microarrays

Adv Mater. 2013 May 14;25(18):2542-7. doi: 10.1002/adma.201204936. Epub 2013 Feb 18.

Abstract

A new class of bacteria-attachment-resistant materials is discovered using a multi-generation polymer microarray methodology that reduces bacterial attachment by up to 99.3% compared with a leading commercially available silver hydrogel anti-bacterial material. The coverage of three bacterial species, Pseudomonas aeruginosa, Staphylococcus aureus, and uropathogenic Escherichia coli is assessed.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Bacterial Adhesion / drug effects*
  • Drug Design*
  • Microarray Analysis*
  • Polymethacrylic Acids / chemistry
  • Polymethacrylic Acids / pharmacology*
  • Pseudomonas aeruginosa / drug effects
  • Pseudomonas aeruginosa / physiology
  • Staphylococcus aureus / drug effects
  • Staphylococcus aureus / physiology

Substances

  • Polymethacrylic Acids
  • polymethacrylic acid