[Malignant transformation of multiple isolated hepatocellular adenomas. Therapeutic implications of immunohistochemical and radiological findings]

Bull Acad Natl Med. 2012 Feb;196(2):459-81; discussion 482-3.
[Article in French]

Abstract

Malignant transformation of hepatic adenoma (HA) is now a well-documented phenomenon. Recent pathological and immunophenotypic studies have identified several subtypes with different prognoses. In many cases the HA subtype can be determined by modern radiological methods, including contrast-enhanced ultrasonography (CEUS) and magnetic resonance imaging (MRI). Based on a series of 26 cases of HA studied with CEUS, MR1 histopathology and immunochemistry, we propose tailored therapeutic options. Watchful waiting is appropriate in some cases, while others require biopsy or resection. Management is more conservative than in previous years.

Publication types

  • English Abstract

MeSH terms

  • Adenoma, Liver Cell / genetics
  • Adenoma, Liver Cell / pathology*
  • Cell Transformation, Neoplastic / pathology*
  • Hepatocyte Nuclear Factor 1-alpha / genetics
  • Humans
  • Immunohistochemistry
  • Inflammation / pathology
  • Liver Neoplasms / genetics
  • Liver Neoplasms / pathology*
  • Mutation
  • beta Catenin / genetics

Substances

  • HNF1A protein, human
  • Hepatocyte Nuclear Factor 1-alpha
  • beta Catenin