Using fluorescent post-labeling to probe the subcellular localization of DNA-targeted platinum anticancer agents

Angew Chem Int Ed Engl. 2013 Mar 18;52(12):3350-4. doi: 10.1002/anie.201210079. Epub 2013 Feb 20.

Authors

Song Ding^#¹, Xin Qiao^#¹, Jimmy Suryadi¹, Glen S Marrs², Gregory L Kucera³, Ulrich Bierbach¹

Affiliations

¹ Department of Chemistry, Wake Forest University, Winston-Salem, NC 27109, USA.
² Department of Biology, Wake Forest University, Winston-Salem, NC 27109, USA.
³ Department of Internal Medicine, Section on Hematology and Oncology, Wake Forest University Health Sciences, Winston-Salem, NC 27157, USA.

^# Contributed equally.

No abstract available

Publication types

Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

MeSH terms

Acridines / chemistry
Antineoplastic Agents / chemistry*
Antineoplastic Agents / metabolism
Cell Line, Tumor
Click Chemistry
DNA, Neoplasm / analysis*
DNA, Neoplasm / metabolism
Fluorescent Dyes / chemistry*
Humans
Hydrazines / chemistry
Microscopy, Confocal*
Platinum / chemistry*

Substances

Acridines
Alexa 488 hydrazide
Antineoplastic Agents
DNA, Neoplasm
Fluorescent Dyes
Hydrazines
Platinum

Grants and funding