Ultrathin PEGylated W18O49 nanowires as a new 980 nm-laser-driven photothermal agent for efficient ablation of cancer cells in vivo

Adv Mater. 2013 Apr 11;25(14):2095-100. doi: 10.1002/adma.201204616. Epub 2013 Feb 21.

Abstract

A new photothermal coupling agent for photothermal ablation (PTA) therapy of tumors is developed based on ultrathin PEGylated W18O49 nanowires. After being injected with the nanowire solution, the in vivo tumors exhibit a rapid temperature rise to 50.0 ± 0.5 °C upon irradiation with NIR laser light at a safe, low intensity (0.72 W cm(-2)) for 2 min (left-hand mouse in the figure),), resulting in the efficient PTA of cancer cells in vivo in 10 min.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • HeLa Cells
  • Humans
  • Infrared Rays*
  • Mice
  • Mice, SCID
  • Nanowires / chemistry*
  • Nanowires / therapeutic use
  • Nanowires / toxicity
  • Neoplasms / therapy
  • Oxides / chemistry*
  • Polyethylene Glycols / chemistry*
  • Surface Plasmon Resonance
  • Temperature
  • Transplantation, Heterologous
  • Tungsten / chemistry*

Substances

  • Oxides
  • Polyethylene Glycols
  • tungsten oxide
  • Tungsten