Abstract
hIAPP fibrillization implicated in Type 2 diabetes pathology involves formation of oligomers toxic to insulin producing pancreatic β-cells. We report design, synthesis, 3D structure and functional characterization of dehydrophenylalanine (ΔF) containing peptides which inhibit hIAPP fibrillization. The inhibitor protects β-cells from hIAPP induced toxicity.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Crystallography, X-Ray
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Humans
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Islet Amyloid Polypeptide / antagonists & inhibitors*
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Islet Amyloid Polypeptide / chemistry
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Models, Molecular
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Peptides / chemical synthesis
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Peptides / chemistry
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Peptides / pharmacology*
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Protein Conformation
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Structure-Activity Relationship
Substances
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Islet Amyloid Polypeptide
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Peptides