A self-adjuvanting supramolecular vaccine carrying a folded protein antigen

Adv Healthc Mater. 2013 Aug;2(8):1114-9. doi: 10.1002/adhm.201200435. Epub 2013 Feb 25.

Abstract

This work illustrates a strategy for the design of molecularly defined immunotherapies, using a blend of supramolecular peptide self-assembly and active site-directed protein capture.

Keywords: biomolecular materials; immunotherapy; nanofibers; proteins; self-assembly.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Adjuvants, Immunologic
  • Amino Acid Sequence
  • Animals
  • Antibodies / blood
  • Antibodies / immunology
  • Antigens / chemistry*
  • Antigens / immunology
  • Green Fluorescent Proteins / chemistry
  • Green Fluorescent Proteins / immunology
  • Mice
  • Mice, Inbred C57BL
  • Nanofibers / chemistry
  • Nitrophenols / chemistry
  • Organophosphonates / chemistry
  • Peptides / chemistry*
  • Peptides / immunology
  • Vaccines, Synthetic / chemistry*
  • Vaccines, Synthetic / immunology

Substances

  • Adjuvants, Immunologic
  • Antibodies
  • Antigens
  • Nitrophenols
  • Organophosphonates
  • Peptides
  • Vaccines, Synthetic
  • Green Fluorescent Proteins
  • 4-nitrophenyl phosphonate