Abstract
One-pot and efficient syntheses of structurally diverse isoquinolin-3-ones and isoquinolin-3-one-based benzo-1,4-diazepin-2,5-diones have been developed. The notable features of the process include the Ugi condensation of monomasked phthalaldehydes with amines, carboxylic acids, and isonitriles, followed by HClO4-mediated intramolecular condensation of the carbonyl with amide.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Amides / chemistry
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Benzodiazepines / chemical synthesis*
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Carboxylic Acids / chemistry
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Combinatorial Chemistry Techniques / methods*
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Cyclization
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Isoquinolines / chemical synthesis*
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Isoquinolines / chemistry
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Nitriles / chemistry
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o-Phthalaldehyde / chemistry
Substances
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Amides
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Carboxylic Acids
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Isoquinolines
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Nitriles
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Benzodiazepines
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o-Phthalaldehyde
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Bz-423