A catalytic and tert-butoxide ion-mediated amidation of aldehydes with para-nitro azides

Chem Commun (Camb). 2013 Apr 7;49(27):2759-61. doi: 10.1039/c3cc40452h.

Abstract

We report here a new catalytic reaction in which, para-nitro azides are acylated by aldehydes to produce amides and molecular nitrogen in a single step. The transformation is believed to proceed via an electron transfer process mediated by the tert-butoxide ion, and catalysed by a thiazolium salt derived species.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Acylation
  • Aldehydes / chemistry*
  • Amides / chemistry*
  • Azides / chemistry*
  • Butanols / chemistry*
  • Catalysis
  • Electron Transport
  • Molecular Structure
  • Nitrogen / chemistry*
  • Nitrogen / metabolism

Substances

  • Aldehydes
  • Amides
  • Azides
  • Butanols
  • Nitrogen