A diamond nanoneedle array for potential high-throughput intracellular delivery

Xianfeng Chen; Guangyu Zhu; Yang Yang; Beilei Wang; Li Yan; Kenneth Yin Zhang; Kenneth Kam-Wing Lo; Wenjun Zhang

doi:10.1002/adhm.201200362

A diamond nanoneedle array for potential high-throughput intracellular delivery

Adv Healthc Mater. 2013 Aug;2(8):1103-7. doi: 10.1002/adhm.201200362. Epub 2013 Feb 27.

Authors

Xianfeng Chen¹, Guangyu Zhu, Yang Yang, Beilei Wang, Li Yan, Kenneth Yin Zhang, Kenneth Kam-Wing Lo, Wenjun Zhang

Affiliation

¹ Center of Super-Diamond and Advanced Films (COSDAF) and Department of Physics and Materials Science, City University of Hong Kong, Hong Kong SAR, P. R. China. [email protected].

PMID: 23447527
DOI: 10.1002/adhm.201200362

Abstract

A dense diamond nanoneedle array is capable of rapidly and conveniently delivering fluorescent probe and drug molecules to a large number of cells. This simple approach paves the way for potential high-throughput delivery of genes, drugs, and fluorescent probes into cells without endocytosis.

Keywords: drug delivery; fluorescent cell probes; high-throughput; intracellular delivery; nanoneedle arrays.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Cell Line, Tumor
Cell Survival / drug effects
Cisplatin / chemistry
Cisplatin / toxicity
Coordination Complexes / chemistry
Diamond / chemistry*
Fluorescent Dyes / chemistry
Humans
Microscopy, Electron, Scanning
Nanostructures / chemistry*
Pharmaceutical Preparations / chemistry
Pharmaceutical Preparations / metabolism*

Substances

Coordination Complexes
Fluorescent Dyes
Pharmaceutical Preparations
Diamond
Cisplatin