Malignant pleural mesothelioma forming a huge mediastinal mass and causing atrial fibrillation

Indian J Pathol Microbiol. 2012 Oct-Dec;55(4):513-5. doi: 10.4103/0377-4929.107794.

Abstract

A patient with malignant pleural mesothelioma was admitted with atrial fibrillation. Chest computed tomography showed a huge mediastinal tumor adjacent to the heart. Autopsy revealed a 12×9.5-cm mediastinal mass involving the right lung, which distorted and stretched the myocardial sleeve surrounding the right inferior pulmonary vein. This case demonstrates that advanced malignant pleural mesothelioma can cause atrial fibrillation, possibly by stimulating myocardium around a pulmonary vein.

Publication types

  • Case Reports

MeSH terms

  • Aged
  • Atrial Fibrillation / etiology*
  • Biomarkers, Tumor
  • Biopsy
  • Calbindin 2
  • Histocytochemistry
  • Humans
  • Immunohistochemistry
  • Lung Neoplasms / complications*
  • Lung Neoplasms / diagnosis*
  • Lung Neoplasms / pathology
  • Male
  • Mediastinal Neoplasms / complications*
  • Mediastinal Neoplasms / diagnosis*
  • Mediastinal Neoplasms / pathology
  • Mesothelioma / complications*
  • Mesothelioma / diagnosis*
  • Mesothelioma / pathology
  • Mesothelioma, Malignant
  • Myocardium / pathology
  • Pleural Neoplasms / complications*
  • Pleural Neoplasms / diagnosis*
  • Pleural Neoplasms / pathology
  • Radiography, Thoracic
  • S100 Calcium Binding Protein G / analysis
  • Tomography, X-Ray Computed

Substances

  • Biomarkers, Tumor
  • Calbindin 2
  • S100 Calcium Binding Protein G