Sodium dodecyl sulphate, a strong inducer of thermostable glucanhydrolase secretion from a derepressed mutant strain of Bacillus alcalophilus GCBNA-4

Appl Biochem Biotechnol. 2013 Apr;169(8):2467-77. doi: 10.1007/s12010-013-0139-9. Epub 2013 Mar 2.

Abstract

In the present study, we report the optimisation of batch conditions for improved α-1,4-glucan-glucanohydrolase (GGH) secretion by a nitrous acid (NA)-treated Bacillus alcalophilus. The wild (isolate GCB-18) and NA-derivative (mutant GCBNA-4) were grown in a medium containing 10 g/L nutrient broth, 10 g/L starch, 5 g/L lactose, 2 g/L ammonium sulphate, 2 g/L CaCl2 and phosphate buffer (pH 7.6). Sodium dodecyl sulphate (SDS) was used as an enzyme inducer while batch fermentations were carried out at 40 °C. The mutant produced GGH in 40 h which was 15-fold higher than the wild in presence of SDS. Thermodynamic studies revealed that the mutant culture exhibited the capability for improved enzyme activity over a broad range of temperature (35-70 °C). The enzyme was purified by cation-exchange column chromatography with ~80 % recovery. The performance of fuzzy-logic system control was found to be highly promising for the improved substrate conversion rate. The correlation (1.045E + 0025) among variables demonstrated the model terms as highly significant indicating commercial utility of the culture used (P < 0.05).

MeSH terms

  • Bacillus / drug effects*
  • Bacillus / enzymology*
  • Enzyme Stability / drug effects
  • Glucosidases / genetics
  • Glucosidases / metabolism*
  • Nitrous Acid / pharmacology
  • Sodium Dodecyl Sulfate / pharmacology*
  • Temperature

Substances

  • Sodium Dodecyl Sulfate
  • 2-O-alpha-D-glucopyranosyl-O-beta-D-galactopyranosyl-hydroxylysine glucohydrolase
  • Glucosidases
  • Nitrous Acid