Abstract
Antibody response constitutes one of the key immune protection mechanisms. T follicular helper (Tfh) cells represent the major CD4⁺ T cell subset that provides help to B cells to induce antibody response. How Tfh cells develop and how Tfh cells or their associated subsets regulate antibody response in humans remains largely unknown. In this review, we will summarize the recent discoveries on the biology of Tfh cells, with a particular focus on human Tfh cells.
Publication types
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Research Support, N.I.H., Extramural
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Review
MeSH terms
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Antibody Formation
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B-Lymphocytes / cytology*
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B-Lymphocytes / immunology
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Cell Differentiation
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Gene Expression
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Germinal Center / cytology*
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Germinal Center / immunology
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Humans
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Palatine Tonsil / cytology*
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Palatine Tonsil / immunology
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Receptors, CXCR5 / genetics
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Receptors, CXCR5 / immunology
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T-Lymphocytes, Helper-Inducer / cytology*
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T-Lymphocytes, Helper-Inducer / immunology
Substances
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CXCR5 protein, human
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Receptors, CXCR5