An additional methylene group driving the conformation and assembly of two arylsulfonamide para-alkoxychalcone hybrids

Acta Crystallogr C. 2013 Mar;69(Pt 3):267-72. doi: 10.1107/S0108270113002291. Epub 2013 Feb 5.

Abstract

The structures of two arylsulfonamide para-alkoxychalcones, namely, N-{4-[(E)-3-(4-methoxyphenyl)prop-2-enoyl]phenyl}benzenesulfonamide, C22H19NO4S, (I), and N-{4-[(E)-3-(4-ethoxyphenyl)prop-2-enoyl]phenyl}benzenesulfonamide, C23H21NO4S, (II), reveal the effect of the inclusion of one -CH2- group between the CH3 branch and the alkoxy O atom on the conformation and crystal structure. Although the molecular conformations and one-dimensional chain motifs are the same in both structures, their crystallographic symmetry, number of independent molecules and crystal packing are different. The crystal packing of (I) is stabilized by weak C-H...π and π-π interactions, while only C-H...π contacts occur in the structure of (II). The role of the additional methylene group in the crystal packing can also be seen in the fact that the alkoxy O atom is an acceptor in nonclassical hydrogen bonds only in the para-ethoxy analogue, (II). The remarkable similarity between the crystal packing features of (I) and (II) lies in the formation of N-H...O hydrogen-bonded ribbons, a synthon commonly found in related compounds.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Benzenesulfonamides
  • Chalcones / chemistry*
  • Crystallography, X-Ray
  • Hydrogen Bonding
  • Molecular Conformation
  • Molecular Structure
  • Sulfonamides / chemistry*

Substances

  • Chalcones
  • N-(4-((E)-3-(4-methoxyphenyl)prop-2-enoyl)phenyl)benzenesulfonamide
  • Sulfonamides