Hydrogen-bond-directed enantioselective decarboxylative Mannich reaction of β-ketoacids with ketimines: application to the synthesis of anti-HIV drug DPC 083

Angew Chem Int Ed Engl. 2013 Apr 2;52(14):3869-73. doi: 10.1002/anie.201210361. Epub 2013 Mar 4.
No abstract available

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Anti-HIV Agents / chemical synthesis*
  • Anti-HIV Agents / chemistry
  • Catalysis
  • Crystallography, X-Ray
  • Hydrogen Bonding
  • Imines / chemistry*
  • Keto Acids / chemistry*
  • Molecular Conformation
  • Nitriles / chemistry*
  • Quinazolines / chemical synthesis*
  • Quinazolines / chemistry
  • Quinazolinones / chemistry
  • Stereoisomerism

Substances

  • Anti-HIV Agents
  • DPC 083
  • Imines
  • Keto Acids
  • Nitriles
  • Quinazolines
  • Quinazolinones
  • ketimine