Comparison of three commercial one-dose porcine circovirus type 2 (PCV2) vaccines on PCV2 shedding in semen from experimentally infected boars

Vet Microbiol. 2013 May 31;164(1-2):145-9. doi: 10.1016/j.vetmic.2013.01.046. Epub 2013 Feb 10.

Abstract

This study compared the effects of 3 different types of commercial PCV2 vaccines on PCV2 virus shedding in the semen from infected boars. Twenty-five non-PCV2 viremic and seronegative boars were randomly divided into five groups: three vaccinated and challenged groups, a non-vaccinated and challenged group, and a negative control group. The number of genomic copies of PCV2 in serum and semen samples was significantly decreased in vaccinated and challenged boars compared to non-vaccinated and challenged boars from 14 to 70 days post-inoculation (dpi). The number of PCV2 genomic copy in the semen correlated with the number of PCV2b genomic copy in the blood in vaccinated and challenged boars (r(2)=0.894-0.926, P<0.01), and non-vaccinated and challenged boars (r(2)=0.903, P<0.01). The vaccination protocol reduced the amount of PCV2 DNA shed in the semen. However, there was a significantly different amount of PCV2 DNA shed in semen among the 3 vaccinated and challenged boar groups.

Publication types

  • Comparative Study
  • Randomized Controlled Trial
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Circoviridae Infections / immunology*
  • Circoviridae Infections / prevention & control
  • Circovirus / classification*
  • Circovirus / genetics
  • Circovirus / isolation & purification*
  • Male
  • Semen / virology*
  • Swine
  • Swine Diseases / immunology
  • Swine Diseases / prevention & control
  • Swine Diseases / virology
  • Viral Vaccines / administration & dosage*
  • Viremia / virology
  • Virus Shedding*

Substances

  • Viral Vaccines