Abstract
Objectives:
To measure Lewis y antigen and CD44 antigen expression in epithelial ovarian carcinoma and to correlate the levels of these antigens with clinical response to chemotherapy.
Methods:
The study cases included 34 cases of ovarian carcinoma with resistance to chemotherapeutic drugs, 6 partially drug-sensitive cases, and 52 drug-sensitive cases (92 total).
Results:
The rates of expression of Lewis y antigen and CD44 antigen were significantly greater in the drug-resistant group than that in the partially-sensitive or sensitive groups. Surgical stage, residual tumor size and expression of CD44 and Lewis y antigen in ovarian carcinoma tissues were independent risk factors for chemotherapeutic drug resistance.
Conclusions:
Over-expression of Lewis y and CD44 antigen are strong risk factors for chemotherapeutic drug resistance in ovarian carcinoma patients.
Publication types
-
Research Support, Non-U.S. Gov't
MeSH terms
-
Carcinoma, Ovarian Epithelial
-
Drug Resistance, Neoplasm / immunology*
-
Female
-
Humans
-
Hyaluronan Receptors / immunology*
-
Immunohistochemistry
-
Lewis Blood Group Antigens / immunology*
-
Middle Aged
-
Multivariate Analysis
-
Neoplasms, Glandular and Epithelial / drug therapy*
-
Neoplasms, Glandular and Epithelial / immunology
-
Ovarian Neoplasms / drug therapy*
-
Ovarian Neoplasms / immunology
Substances
-
Hyaluronan Receptors
-
Lewis Blood Group Antigens
-
Lewis Y antigen
Grants and funding
This work is supported by the National Natural Science Foundation of China (No. 30872757, 81072118, 81172491, 81101527); Ph.D. Programs Foundation of Ministry of Education of China (No. 20112104110016, 20112104120019); Science Committee Foundation of Shenyang City, China (No. F10-14-9-9-52); Shengjing Free Researcher Project (No. 200807). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.