Abstract
Amomaxins A (1) and B (2), featuring an unprecedented rearranged labdane norditerpene skeleton with a nine-membered ring, along with their biosynthetic related known compound isocoronarin D (3) were isolated from the roots of Amomum maximum. Their structures with absolute configurations were determined by spectroscopic data, CD experimentation, and single-crystal X-ray diffraction. Compound 2 showed an inhibitory effect on nitric oxide (NO) production in lipopolysaccharide-induced RAW264.7 macrophages.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Amomum / chemistry*
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Animals
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Crystallography, X-Ray
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Cytotoxins / chemistry*
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Cytotoxins / isolation & purification*
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Cytotoxins / pharmacology
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Diterpenes / chemistry*
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Diterpenes / isolation & purification*
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Diterpenes / pharmacology
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Drugs, Chinese Herbal / chemistry*
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Drugs, Chinese Herbal / isolation & purification*
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Drugs, Chinese Herbal / pharmacology
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Inhibitory Concentration 50
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Lipopolysaccharides / pharmacology
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Macrophages / drug effects
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Mice
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Molecular Conformation
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Molecular Structure
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Nitric Oxide / biosynthesis
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Nuclear Magnetic Resonance, Biomolecular
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Plant Roots / chemistry
Substances
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Cytotoxins
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Diterpenes
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Drugs, Chinese Herbal
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Lipopolysaccharides
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amomaxin A
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amomaxin B
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Nitric Oxide