Novel SIRT1 mutation linked to autoimmune diabetes in humans

Jing W Hughes; Kevan C Herold

doi:10.1016/j.cmet.2013.02.014

Novel SIRT1 mutation linked to autoimmune diabetes in humans

Cell Metab. 2013 Mar 5;17(3):311-2. doi: 10.1016/j.cmet.2013.02.014.

Authors

Jing W Hughes¹, Kevan C Herold

Affiliation

¹ Departments of Immunobiology and Internal Medicine, Yale University School of Medicine, 300 George Street, New Haven, CT 06511, USA.

Abstract

Sirtuins are best known for their role in aging but also regulate many different biological processes. A study in this issue of Cell Metabolism (Biason-Lauber et al., 2013) now identifies a mutation in human SIRT1 causing a familial form of autoimmune diabetes.

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