Abstract
Polymeric micelles and shell crosslinked knedel-like (SCK) nanoparticles were loaded with up to 48% (w/w) cisplatin. These spherical cisplatin-loaded nanoparticles displayed sustained platinum release over 5 days in PBS, enhanced stability over free cisplatin in aqueous milieu, and significant antitumor activity in vitro against two cancer cell lines.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Antineoplastic Agents / administration & dosage
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Antineoplastic Agents / pharmacokinetics
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Cells, Cultured
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Cisplatin / administration & dosage*
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Cisplatin / pharmacokinetics
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Coated Materials, Biocompatible / chemical synthesis
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Coated Materials, Biocompatible / chemistry
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Coated Materials, Biocompatible / pharmacokinetics
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Coated Materials, Biocompatible / pharmacology
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Cross-Linking Reagents / pharmacology*
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Drug Carriers / chemical synthesis*
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Drug Carriers / chemistry
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Drug Delivery Systems
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Drug Evaluation, Preclinical
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Drug Stability
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Humans
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Mice
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Micelles
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Models, Biological
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Nanoparticles / chemistry*
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Nanoshells / chemistry
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Particle Size
Substances
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Antineoplastic Agents
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Coated Materials, Biocompatible
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Cross-Linking Reagents
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Drug Carriers
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Micelles
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Cisplatin