Abstract
Gamma interferon (IFN-γ)-mediated host responses play a central role in resolving genital Chlamydia trachomatis infections but may also result in persistence of the pathogen, which shows reduced susceptibility to antimicrobials. The antichlamydial function of IFN-γ is oxygen dependent, and the efficacy of antimicrobials against C. trachomatis is reduced in a low-oxygen environment. In this study, we show that the antichlamydial efficacies of azithromycin and doxycycline differ in IFN-γ-treated cells under hypoxia.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Anti-Bacterial Agents / pharmacology*
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Anti-Bacterial Agents / therapeutic use
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Azithromycin / pharmacology*
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Azithromycin / therapeutic use
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Cell Hypoxia
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Chlamydia Infections / drug therapy
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Chlamydia Infections / microbiology
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Chlamydia trachomatis / drug effects*
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Doxycycline / pharmacology*
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Doxycycline / therapeutic use
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HeLa Cells / drug effects
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HeLa Cells / microbiology
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Humans
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Interferon-gamma / pharmacology*
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Interferon-gamma / therapeutic use
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Oxygen / pharmacology*
Substances
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Anti-Bacterial Agents
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Interferon-gamma
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Azithromycin
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Doxycycline
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Oxygen