[Pancreatic cancer in the elderly: guidelines and individualized therapy]

Chirurg. 2013 Apr;84(4):291-5. doi: 10.1007/s00104-012-2455-y.
[Article in German]

Abstract

The considerable increase of the aged population in western civilisation within the next years will result in a rising incidence of pancreatic cancer. Until the year 2020 an increment of 20 % of patients beyond 65 years old can be anticipated. Therefore, the focus will be on management of old and geriatric surgical patients leading to strategical re-evaluation of surgical indications under critical consideration of feasibility and purpose. Even under modern interdisciplinary therapy concepts the prognosis of ductal adenocarcinoma of the pancreas remains poor with an overall 5-year survival rate of less than 5 %. The surgical resection is still considered as the only potential curative treatment option with extended life expectancy; however, it is technically demanding and furthermore associated with significant morbidity. In particular, the quality of surgery of the now interdisciplinary therapy of pancreatic cancer is markedly improved when performed at a high-volume centres. Until now only a few retrospective data analyses evaluating the perioperative and long-term outcome after pancreatic tumor resections in geriatric patients exist. The available results, however, support radical surgical procedures even beyond the age of 75 years.

Publication types

  • English Abstract
  • Review

MeSH terms

  • Age Factors
  • Aged
  • Aged, 80 and over
  • Carcinoma, Pancreatic Ductal / mortality
  • Carcinoma, Pancreatic Ductal / pathology
  • Carcinoma, Pancreatic Ductal / surgery*
  • Cooperative Behavior
  • Disease Progression
  • Female
  • Germany
  • Guideline Adherence*
  • Hospitals, High-Volume
  • Humans
  • Interdisciplinary Communication
  • Male
  • Mesenteric Veins / pathology
  • Mesenteric Veins / surgery
  • Neoplasm Invasiveness
  • Neoplasm Staging
  • Pancreatectomy / methods
  • Pancreatectomy / mortality
  • Pancreatic Neoplasms / mortality
  • Pancreatic Neoplasms / pathology
  • Pancreatic Neoplasms / surgery*
  • Pancreaticoduodenectomy / methods
  • Pancreaticoduodenectomy / mortality
  • Patient Care Planning*
  • Portal Vein / pathology
  • Portal Vein / surgery
  • Prognosis
  • Survival Rate
  • Treatment Outcome